Project Description
Microfluidic NGS Library Prep and Cell Editing System
Client: Miroculus
Our Role:
- Developed a cartridge and instrument interface module for a system that simplifies, automates, and miniaturize complex protocols, such as NGS library prep, in a compact and user-friendly system
- Perform design, prototype, and assembly work
Unique Features and Accomplishments:
- Microfluidic technology moves droplets through multistep protocols without user intervention
- The system senses and detects any misplaced droplets
- The cartridge is “oil-free” in that it does not use oil to encapsulate the droplets, and is therefore not prone to leaking
- The device can apply mechanically vigorous methods without fear of emulsions, making it compatible with ethanol and other chemicals that interact with oil
- The disposable cartridge does not require electronics within it; the electronics are all in the controller.
- System supports protocols with up to 12 reagents and three large volume wash reagents
Expertise Employed:
While all projects benefit from our development process and expertise in design, engineering, and in-house rapid prototyping, this project highlights our expertise in: